International Journal of Engineering, Science and Mathematics
(IJMRA Publications)-
Peer Reviewed Refereed Journal
 

...

Pages: 148-160

Date of Publication: 30-Nov--0001

SYNTHESIS, SPECTRAL, THERMAL CHARACTERIZATION, ELECTROCHEMICAL APPLICATIONS AND PHARMACOLOGICAL STUDIES OF TRANSITION METAL COMPLEXES OF THIOSEMICARBAZIDE LIGANDS DERIVED FROM 4, 4- DIAMINODIPHENYLSULPHONE

Author: P. Chandra Menaga* V. Rama**

Category: Engineering, Science and Mathematics

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Abstract:

Novel metal complexes of Co(II) and Cu(II) with 4-(4__ampersandsign#39;-(4-aminophenyl)sulfonylphenyl)-3-thiosemicarbazide (DSC), 4-(4__ampersandsign#39;-(4(2-hydroxyphenylmethylene)-aminophenyl)sulfonylphenyl)-3-thiosemi carbazide (SSC) , 4-(4__ampersandsign#39;-(4-thiophen-2-ylmethyleneaminophenyl)-sulfonylphenyl)-3-thiosemicarbazide (TSC) and 4-(4__ampersandsign#39;-(4(3,4-dimethoxy-phenylmethylene)aminophenyl)sulfonylphenyl)-3-thiosemicarbazide (DMSC) have been prepared and characterized by elemental analyses, spectral (UV, IR and NMR) studies, thermal analysis and molar conductance measurements. The metal complexes and the ligands were tested for antimicrobial property and the corrosion studies were carried on mild steel surface. The analytical data confirmed the metal: ligand stoichiometry of the complexes was 1:1 type in [M(L)Cl2] (where __ampersandsign#39;M__ampersandsign#39; stands for Cu and Co ; L = SSC, TSC, DMSC) and 1:2 type in [M(L2)Cl2] (where __ampersandsign#39;M__ampersandsign#39; stands for Cu and Co ; L = DSC). The spectral data suggested the involvement of thione sulphur and azomethine nitrogen in coordination to the central metal ion and octahedral geometry for Co(II) and Cu(II) complexes. The corrosion inhibition characteristics of thiosemicarbazides and its metal complexes on mild steel in 0.1 M HCl solution was studied by chemical method. The adsorption of inhibitors on mild steel surface obeyed Langmuir, Frumkin and Temkin adsorption isotherm. The calculated thermodynamic parameters for adsorption reveals a strong interaction between the inhibitors and the mild steel surface. Antibacterial studies infer that, cobalt complexes showed the highest antifungal and antibacterial activities.

Keywords: Thiosemicarbazide; 4, 4-diaminodiphenylsulphone; Metalcomplexes; Antimicrobial Activity; Corrosion study.