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INTERNATIONAL JOURNAL OF ENGINEERING, SCIENCE AND - Volume 7, Issue 4 (3) , April 2018 (Special Issue FBSA)

Pages: 91-93
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Exposure to isoflavones in diet is not good for reproductive health of premenopausal women ---- A short review.

Author: Indraneel Saha *

Category: Engineering, Science and Mathematics


Isoflavones, plant secondary metabolite, abundant in Soy (Glycine max) are genistein, daidzein and glycitein. They bind to and activate intracellular estrogen receptors: ERα and ERβ mimicking the effects of estrogen. Estrogen-like effects have raised concern regarding soy/isoflavones consumption particularly in the case of postmenopausal women at high risk of breast cancer. It causes an increase in estrogen which stimulates the uterus in a continuous manner and inhibits implantation which can lead to sub fertility or infertility. Increased estrogen signaling in ovary would most likely result in the negative feedback action of estrogen which reduces ovulation. It has been found that soy intake in human causes a decrease in midcycle gonadotropins, increased cycle length, abnormal uterine bleeding, endometrial pathology, dysmenorrheal, lower estradiol and progesterone and serum hormone binding globulin (SHBG). The review dealt with the effect of isoflavones on female reproductive system particularly.

Keywords: Isoflavones; Dysmenorrhoea; SHBG; Gonadotropin ;