INTERNATIONAL JOURNAL OF ENGINEERING, SCIENCE AND - Volume 6, Issue 3, July 2017

Pages: 76-82

Date of Publication: 01-Jul-2017

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CONVENIENT AND EFFICIENT SYNTHESIS OF SOME NOVEL CHOLIC ACID DERIVATIVE AND ITS ANTIMICROBIAL EVALUATION

Author: Mohit lagdhira, Chintan pandyaa*, Aditee pandyab, Denish kariac

Category: Engineering, Science and Mathematics

Abstract:

A convenient and competent synthesis of a series of eleven new Cholic acid derivative (A-K) is described starting from Cholic acid. The invitroantimicrobial estimation of the newly synthesized Cholic acid derivative was performed against four bacterial strains i.e.two Gram-positive bacteria viz. Bacillus subtilis(MTCC 441) & Staphylococcus epidermidis(MTCC 6880), two Gram-negative bacteria viz. Escherichiacoli(MTCC 1652) & Pseudomonas aeruginosa(MTCC 424) and twofungal strains viz. Candida albicans(MTCC 227) & Aspergillus niger(MTCC 8189) by sequential dilution technique. The derivatives 2e, 2f, 2gand 2kwere found to exhibit better antibacterial activity than other tested compounds against B. S.epidermidis.

Keywords: Cholic acid , HATU(1-[Bis(dimethylamino)methylene]-1H-1, 2, 3-triazolo[4, 5-b] pyridinium 3-oxid hexafluorophosphate), Antimicrobial