INTERNATIONAL JOURNAL OF ENGINEERING, SCIENCE AND - Volume 6, Issue 2 , June 2017

Pages: 57-64

Date of Publication: 01-Jun-2017

Print Article   Download XML  Download PDF

 

 SYNTHESIS OF N-SUBSTITUTED HYDROXAMIC ACIDS

Author: D. N. Sharma* S. K. Rajput**

Category: Engineering, Science and Mathematics

Abstract:

A series of N-substituted hydroxamic acids, R.N(OH).C(O).R’, have been synthesized by reacting freshly prepared N-substituted hydroxylamines and acid chlorides in mixed diethyl ether and petroleum ether (boiling range 40 to 600 C) media at 0 to 50 C, and neutralizing the liberated hydrochloric acid with aqueous suspensions of sodium bicarbonate. These compounds have been prepared for analytical applications and physico-chemical studies. These are also to be examined for antibacterial, antifungieidal and antiviral activity. The melting points of these compounds are as under. R=-C6H4CH3-4, R’= -C6H4F-3, 990 : -C6H4Cl-3, 990; -C6H3Cl2-2,4, 1630; -CH2 Cl, 1230; -(CH2)7 CH3, 820; - (CH2)8 CH3, 860; - (CH2)2C6H5, 1180; - (CH)2C6H5, 1560; -(CH3O)2C6H3-3,5, 1300; -C4H3, 1310 R=-C6H4CH3-3, R’= -C (CH3)3, 1050 : R=-C6H4Cl-4, R’= -(CH2)14CH3, 1000 : R=- CH2C6H5, R’= -C (CH3)3, 1040 : -(CH2)14CH3, 940 :

Keywords: substituted phenyl, 2 – furyl or alkyl group