Abstract
INTERNATIONAL JOURNAL OF ENGINEERING, SCIENCE AND - Volume 7, Issue 1, January 2018
Pages: 543-552
A KINETIC STUDY OF AQUO-ETHANOL REACTION MEDIA ON THE PHARMACEUTICAL EFFICIENCY OF SOLVOLYSIS PRODUCES OF NICOTINATES.
¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬ZEBA PARWEEN* AND R. T. SINGH**
Category:Engineering, Science and Mathematics
Abstract:
For studying the solvent effect of aquo-ethanol solvent systems on the insecticidal efficiency of the Solvolysis Products of nicotinate ester the kinetics of alkali catalysed hydrolysis of methyl nicotinate was studided in aquo-EtOHmedia having varying concentration of ethanol from 20 to 80% (v/v) al five different temperatures ranging from 20 to 40°C. From enhancement and depletion found in EC and ED values respectively is due to Solvation and desolvation of unitial and transition State to different extent. With decreasing number of water molecules from 1.341 to 0.329 with increasing temperature from 20 to 40°C, it is concluded that the mechanism of the reaction is changed from unimolecular to bimolecular with addition of ethanol in the reaction media. Simulatineously increase in all the three thermodynamic activation parameters i.e. ?H*, ?S* and ?G*, it may be inferred that the solvent ethanol acts enthalpy stimulator and entropy controlled. From the evaluated numerical value of Iso-Kinetic temperature of the reaction, i.e. 321.10, it is concluded that due to strong solvent solute interaction in aquo-ethanol media it may be used for manufacturing insecticide of desired strength.
Keywords: Pharmaceutical Effieiency, Nicotinates, Insecticide, Solvolysis Iso-Kinetic Temperature, entropy controlled